Applications with web service components, like Adobe Creative Cloud and Microsoft Office 365, should be removed according to the instructions on the developer’s website. If possible, you should always default to using the applications uninstaller, if it has one.
Although, this happens with some Mac apps as well, as you’ll see if you try to manually uninstall more complex applications. Compare this to Windows, where an installer can spew files across the system in dozens of arbitrary locations. On macOS, applications generally like to stay inside their. In some cases it can leave behind gigabytes of data. However, that typically leaves behind at least a few preference files.
Depending on the application and the installation method, you may be able to completely uninstall an application from macOS by simply dragging the.